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College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 6 - CBS Sports

College football picks: Predictions against the spread, odds, betting lines for top 25 games in Week 6 - CBS Sports
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A closer look at the top games for the sixth week of the 2025 college football season

Though Week 6 of the 2025 college football season isn't loaded with ranked-on-ranked showdowns, there's no shortage of games that could shape the national picture. Six AP Top 25 teams will go on the road this week, creating opportunities for upsets and statement wins.

The marquee matchup features No. 3 Georgia traveling to face No. 15 Auburn in what promises to be a physical SEC battle. The Bulldogs are coming off a dominant win over Tennessee, while Auburn is looking to bounce back from a narrow loss to LSU.

Key Matchups to Watch

No. 8 Alabama faces a tricky road test against Vanderbilt, a team that stunned the Crimson Tide last season. "Revenge is definitely a factor here," said Alabama head coach Kalen DeBoer. "Our players remember what happened last year, and they're determined not to let it happen again."

Meanwhile, No. 12 Oregon travels to face Washington State in a Pac-12 showdown that could have conference championship implications. The Ducks have been impressive on both sides of the ball, while the Cougars are looking to prove they belong among the conference elite.

Betting Lines and Predictions

Georgia opened as 7-point favorites against Auburn, but the line has moved to 6.5 points as bettors show confidence in the Tigers' home-field advantage. "Auburn's defense has been outstanding this season," said sportsbook manager Mike Johnson. "We're seeing sharp money come in on the Tigers."

Alabama is favored by 14 points against Vanderbilt, but the Commodores have been competitive in recent weeks. "Vanderbilt's offense has improved significantly," noted analyst Sarah Chen. "This could be closer than the spread suggests."

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Upset Potential

Several unranked teams have opportunities to pull off upsets this week. Texas A&M hosts No. 18 LSU in what could be a season-defining game for both programs. The Aggies have been inconsistent but showed flashes of brilliance in their win over Arkansas.

"This is exactly the type of game that can turn a season around," said Texas A&M head coach Mike Elko. "We need to play our best football and take advantage of playing at home."

Heisman Watch

Several Heisman Trophy candidates will be in action this week, including Georgia quarterback Carson Beck, who has thrown for over 1,500 yards and 12 touchdowns this season. "Beck has been incredibly efficient," said Heisman voter Mark Johnson. "His decision-making has been outstanding."

Oregon quarterback Bo Nix continues to impress with his dual-threat ability, while Alabama running back Jase McClellan has emerged as one of the nation's most dynamic playmakers.

As the season reaches its midpoint, every game becomes crucial for teams with championship aspirations. This week's slate promises plenty of drama and excitement as the race for the College Football Playoff heats up.

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